For example, the GUT_0 is always 0 no matter what values in the GUT. I was not able to assign the initial values the way I want through the $MAIN section. Second scenario: TOD matched with TIME perfectlyĮ <- ev(time=1, amt=150, ii=1, addl=127, evid=1) In a SC, dose superimposition was implemented solely using NM-TRAN abbreviated code and the maximum number of the doses that can be administered for any subject must be pre-defined. For implementation in NONMEM, we discussed a special case (SC) and a general case (GC). I did some tests using the simple TOD code.įirst scenario: TOD stays at 1 all the time (does not change with TIME)Į <- ev(time=1, amt=150, ii=1, addl=12 7, evid=3) The code for implementing the dose superimposition in WinNonlin and NONMEM was provided. Sounds like EVID=3 only works when it first appeared in the dataset, not later.
However, I experienced some difficulties in mrgsolve. The SS and ADDL data items must be combined with II.
It is only needed for zero-order input models. The RATE data item is frequently set to -2 so that the duration of a zero order input can be estimated. The default value is typically compartment 1. This item is not required but is often useful. I did the similar settings in NONMEM and it works as expected. which compartment the AMT should be put into. Also, the PD compartments were re-initialized depending on the model predicted values (G0, G1 or G2). Since only the PD compartments need to be reset, I tent to re-initialize the PK compartments to the exact value before the reset. ADVAN12 1DEPOT 2CENTRAL 3PERIPHERAL 1 4PERIPHERAL 2 5OUTPUT TRANS1 KA, K, K23, K32, K24, K42 Three Compartment Linear Mammillary Model with First Order. The model include both the PK and PD compartments, and as expected EVID=3 will clear out the whole system. I am working on a model that need EVID=3 to reset the system and reinitialize the compartments.
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